Cetpro™ KA (Kojic acid) is produced through a bio-fermentation process and can inhibit tyrosinase activity in the synthesis of melanin. This helps with skin brightening and the reduction of fine lines and wrinkles. This acid is also known to be enriched with antibacterial properties. 

Mode of action

Kojic acid works in vivo through its involvement with NF-κB. In a cell, NF-κB is inhibited by a protein called IκB. With UV light and other activators, IκB degrades and NF-κB is freed and can translocate to the nucleus and affect expression of certain genes. One particular example of a gene expression that can change is that of melanotrophic factors, meaning NF-κB, when active, can cause increased melanin production. In a study, several melanogenic inhibitors (niacinamide, kojic acid, hydroquinone, resorcinol, arbutin, and glycolic acid) were tested and Kojic acid was found to be the most potent inhibitor of UVB-induced NF-κB activation. The inhibitory activity of Kojic acid was also more potent than known antioxidants such as vitamin C and N-acetylL-cysteine.

Benefits

• Skin brightening
• Anti-aging
• Scar lightening
• Antibacterial